Telomerase Activation

Telomerase Activation works on targeted cells in your body and can improve not only cell longevity but quality of life.

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A double-blind, placebo controlled study of TA-65® showed improvements in:

  • immune system
  • vision
  • male sexual performance
  • skin appearance
  • and more.

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Learn more about the new world of telomerase activation as a method to intervene in the aging process. Understand how taking TA-65 may improve your health and vitality. Find out your real biological age by testing your biomarkers of aging and measuring the length of your telomeres.

Telomere Science

There are trillions of cells in our body and at any given time a great number are dividing furiously to keep us alive and well. The process is directed by genes sitting on the 23 pairs of chromosomes found in the nucleus of each and every cell. The chromosomes are long sequences of DNA that contain all our genetic material. Each pair of chromosomes consists of one from your mother and one from your father and they are twisted around each other to form a structure called the double helix.

Of particular interest to the scientists at T.A. Sciences are the ends of each chromosome known as telomeres. Telomeres have no genetic function; they are simply stretches of DNA (repeats of base pairs) that protect the rest of the chromosome. These little bits of DNA are critical to healthy cell function and have been likened to the plastic tips on shoelaces because they prevent the chromosome from “fraying.”

However, telomeres become progressively shorter each time the cell divides. When they get too short, cells reach replicative senescence and can no longer divide. The result can be the various conditions associated with old age.

Scientists have only recently begun to understand the critical importance of shortened telomeres. Research has shown that people over sixty who have long telomeres experience greater heart and immune system health than their age-matched counterparts with shorter telomeres. Thus, it is becoming well-understood that maintaining telomere length is preventing age-related decline.

The phenomenon of cellular aging was first noted by Professor Lenhard Hayflick in 1961. He discovered that cells cannot divide beyond a specific number of times. This is called the Hayflick Limit. Cells reaching this limit become old. Although Professor Hayflick discovered this important scientific principle, he had no idea what caused it.

It took almost thirty more years before the role telomeres play in cellular aging was finally understood. In 1990, Calvin Harley at McMaster University in Canada and Carol Greider at Cold Spring Harbor Laboratory in the USA discovered that telomere shortening goes hand-in-hand with the aging process and is the direct cause of cells reaching the Hayflick Limit.

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TA-65 Studies

Commentary by Anthony Loera

Safety and Effectiveness Study:

(TA Sciences 2013, Unpublished).This study evaluated 125 healthy adult humans in a Double Blind Placebo Controlled (DBPC) study. Providing two capsules a day for 30 days. Safety Parameters: The study measured safety parameters including blood pressure, body temperature, blood glucose, liver function, kidney function, thyroid stimulating hormone, pH blood, pH saliva, and pH Urine. Efficacy Parameters: Homocysteine, C-reactive protein, T-cell (CD4 and CD8), nitrates, and oxidation reduction potential (blood, urine, saliva). The preliminary clinical analysis of safety and effectiveness of TA-65 shows that the product is safe and effective for short term use in humans.

Telomere Length Maintenance Study:

(Rejuvenation Res. 2011, 14(1):45-56) The study reports on the first year of taking TA-65 with a dietary supplement pack and doctor visits and tests. Low nanomolar levels of TA-65 moderately activated telomerase in human keratinocytes, fibroblasts and immune cells in culture, while similar plasma levels of TA-65 were achieved in pilot human pharmocokinectic studies. In Vivo: The most striking in vivo effects where declines in senescent cytotoxic T-Cells. Although Mean telomere did not increase, there was a significant reduction in the percent of short telomeres. The study concluded that the protocol that used TA-65 lengthens critically short telomeres.

Metabolic and Cardiovascular Biomarkers study:

(Rejuvenation Res. 06/2013) Over a period of 5 years no adverse events or effects have been attributed to TA-65 by physicians licensed to sell the product. Various improvements where shown in fasting glucose, insulin, LDL-cholesterol, systolic and diastolic blood pressure and homocysteine levels. While some individuals showed an increase in bone density in the spine. Author concluded that in addition to the apparent immune remodeling, that the protocol may also improve markers of metabolic, bone and cardiovascular for many people.

Safety sub-chronic toxicity study:

Toxicity study showed no effects attributable to the TA-65 ingredient orally administered to animals. The no observed effect level of the ingredient was at a very high amount of 150 mg per kilogram of body weight. Normal humans would never reach anywhere close to that amount using the TA-65 protocol.

Genotoxicity studies:

  • Bacterial reverse mutation assay: Found no cytotoxicity and no mutagenic response was observed.
  • In Vitro chromosomal aberration assay: No dose-response relationship was observed. The aberration rates for 2 of the groups fell within the range of historical control data.
  • In Vivo erythrocyte micronucleus assay: Under the study conditions TA-65 was not clastogenic and/or aneugenic. The TA-65 ingredient did not induce structural and/or numerical chromosomal damage in immature erythrocytes of animals.

Carcinogenicity study:

A Xenographeted Mice Study (TA Sciences Unpublished): Using 5 mg per kilogram of body weight of the animals with attached human tumors. The study showed no treatment related effect on survival (mean or maximum) was observed. The summary TA-65 at a level of 25mg per kilogram of animal bodyweight for 4 months was well tolerated in aged mice with no effect on survival and no increase in malignant incidence.

Topical Study (TA Sciences Unpublished):

TA-65 applied topically on experimental created lesions in animals under anesthesia, showed significantly greater cell density, significantly more regularly organized dermis and significantly more newly formed blood vessels than placebo treated wounds.

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